Arginine ‘Magic’ Established in Accounts

We knew that guanidinium cation is an unique species, which desire our attention. Its ability to form cation-cation pairs is manifested in aqueous solutions of guanidinium salts as well as between arginine sidechains in proteins. Gdm-stackingSuch arginine magic was pointed out to lead to an unexpected attraction between polyarginine chains with consequences to the action of arginine-rich cell penetrating peptides.

For more, check our recent review in Accounts of Chemical Research.
doi: 10.1021/acs.accounts.8b00098

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